Welcome Yujie Li
Yujie joins us from the University of Chicago where she completed her Ph.D. with David Kovar. For her graduate work, Yujie worked on developing in vitro assays for imaging molecular interactions with actin filaments.
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Clint publishes paper on Journal of Cell Biology
Congratulations to graduate student, Clint Ko, on publishing his research titled Microtubules promote intercellular contractile force transmission during tissue folding in the Journal of Cell Biology. Clint discovered that microtubules maintain intercellular adhesion by regulating actin.
Mary Ann Collins publishes paper from her PhD work in MBoC
Postdoc Mary Ann Collins publishes paper from her PhD work in Molecular Biology of the Cell. One of her microscopy images was selected for the cover!
Mimi Xie’s paper in Nature Communications
Congratulations to graduate student, Mimi Xie, for her publication “Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding” in Nature Communications. In the paper, Mimi showed that cells exhibit three classes of contractile events, unconstricting, unratcheted, and ratcheted. Mimi demonstrated that cells undergo transitions between different classes of contractions, going from unconstricting or unratcheted contractions to ratcheted contractions. A transcription factor that regulates this developmental stage is important for the proper order of contractile events. It is important for cells to generate ratcheted contractions because this promotes cooperation between cells.
Welcome new lab members
We have a number of new additions to the lab including postdocs Jasmin Imran Alsous and Nat Clarke, graduate students Anna Yeh and Jaclyn Camuglia, undergraduates Prateek Kalakuntla and Jennifer Nwako, and technician Vardges Tserunyan.
Hannah publishes Developmental Cell paper
Postdoctoral fellow, Hannah Yevick, published her research titled Structural redundancy in supracellular actomyosin networks enables robust tissue folding in Developmental Cell. You can hear her talk about what she discovered in the video produced by Raleigh McElvery of the MIT Biology department. Read an MIT News article on the research.
Mimi Xie publishes MBoC paper
Congratulations Mimi Xie for publishing her work “Loss of Gα12/13 Exacerbates Apical Area-dependence of Actomyosin Contractility” in Molecular Biology of the Cell! Mimi showed how apical actin density can depend on apex size. Suppressing this dependence is important to coordinate contractility across a tissue.