Congratulations to Soline on publishing her work “Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Cell Force” in Nature Communications. Soline discovered a mechanism by which tissue and organism shape can instruct cells how to generate force. This has implications in understanding how tissues and organs acquire their correct shape.
Congratulations to graduate student, Mimi Xie, for her publication “Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding” in Nature Communications. In the paper, Mimi showed that cells exhibit three classes of contractile events, unconstricting, unratcheted, and ratcheted. Mimi demonstrated that cells undergo transitions between different classes of contractions, going from unconstricting or unratcheted contractions to ratcheted contractions. A transcription factor that regulates this developmental stage is important for the proper order of contractile events. It is important for cells to generate ratcheted contractions because this promotes cooperation between cells.
Graduate student, Jaclyn Camuglia, submitted her research “Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation” and posted a preprint. We found that morphogenetic forces are required to orient cell divisions in the Drosophila embryo through a mechanism that establishes polarity of the Pins protein.
Congratulations Claudia on publishing her work “Drosophila Non-muscle Myosin II Motor Activity Determines the Rate of Tissue Folding” in eLife. Claudia demonstrated that myosin 2 motor activity sets the rate of apical constriction and tissue folding, showing that myosin 2 is the motor that drives these processes. This work was the result of a great collaboration with James Sellers’ lab at the National Institutes of Health.
Jonathan Coravos gave an amazing seminar and successfully defended his thesis. Well done Jonathan! Have fun in Chile!
Congratulations Elena Kingston on winning the best poster prize at the Building 68 retreat. We have won a poster prize each year for the past 3 years. Nice job Mimi, Claudia, and now Elena.
Congratulations grad student, Marlis Denk-Lobnig, on her paper titled Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature being published by Development.