Marlis featured in MIT Biology news
Congratulations to graduate student, Marlis Denk-Lobnig, who was featured in the MIT Biology department news. Read the article.
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Frank Mason publishes Nature Cell Biology paper
Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.
Welcome Babli Adhikary!
Babli is doing summer research as part of the prestigious Khorana Scholars Program.
Jeanne Jodin publishes Developmental Cell paper
Congratulations Jeanne Jodin, for publishing her work “Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover” in Developmental Cell. Jeanne showed that stable force balance between cells in a tissue requires robust actin filament turnover. The paper was also highlighted by the journal. Read the paper and the highlight article.
Soline publishes Nature Communications paper
Congratulations to Soline on publishing her work “Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Cell Force” in Nature Communications. Soline discovered a mechanism by which tissue and organism shape can instruct cells how to generate force. This has implications in understanding how tissues and organs acquire their correct shape.
Welcome Clint Ko
Biology graduate student, Clint Ko, is joining our lab. Clint was an undergrad at Cornell University where he worked on plant development. We are happy he has turned to the fruit fly for his next system.
Frank Mason publishes Nature Cell Biology paper
Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.
Welcome Babli Adhikary!
Babli is doing summer research as part of the prestigious Khorana Scholars Program.
Jeanne Jodin publishes Developmental Cell paper
Congratulations Jeanne Jodin, for publishing her work “Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover” in Developmental Cell. Jeanne showed that stable force balance between cells in a tissue requires robust actin filament turnover. The paper was also highlighted by the journal. Read the paper and the highlight article.
Soline publishes Nature Communications paper
Congratulations to Soline on publishing her work “Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Cell Force” in Nature Communications. Soline discovered a mechanism by which tissue and organism shape can instruct cells how to generate force. This has implications in understanding how tissues and organs acquire their correct shape.
Welcome Clint Ko
Biology graduate student, Clint Ko, is joining our lab. Clint was an undergrad at Cornell University where he worked on plant development. We are happy he has turned to the fruit fly for his next system.
Frank Mason publishes Nature Cell Biology paper
Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.
Welcome Babli Adhikary!
Babli is doing summer research as part of the prestigious Khorana Scholars Program.
Jeanne Jodin publishes Developmental Cell paper
Congratulations Jeanne Jodin, for publishing her work “Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover” in Developmental Cell. Jeanne showed that stable force balance between cells in a tissue requires robust actin filament turnover. The paper was also highlighted by the journal. Read the paper and the highlight article.
Soline publishes Nature Communications paper
Congratulations to Soline on publishing her work “Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Cell Force” in Nature Communications. Soline discovered a mechanism by which tissue and organism shape can instruct cells how to generate force. This has implications in understanding how tissues and organs acquire their correct shape.
Welcome Clint Ko
Biology graduate student, Clint Ko, is joining our lab. Clint was an undergrad at Cornell University where he worked on plant development. We are happy he has turned to the fruit fly for his next system.