Congratulations Dr. Coravos
Jonathan Coravos gave an amazing seminar and successfully defended his thesis. Well done Jonathan! Have fun in Chile!
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Mary Ann Collins publishes paper from her PhD work in MBoC
Postdoc Mary Ann Collins publishes paper from her PhD work in Molecular Biology of the Cell. One of her microscopy images was selected for the cover!
Hannah Yevick starts Assistant Professor position
Dr. Yevick starts as an Assistant Professor at Brandeis University. Check out her new lab website. Congratulations and good luck, Hannah!
Clint and Prateek publish paper in Molecular Biology of the Cell
Graduate student Clint Ko and Undergraduate Prateek Kalakuntla publish MBoC paper on how mitotic entry can repress ‘active’ contractility and result in relaxation that promotes neighboring tissue folding.
Mimi Xie publishes MBoC paper
Congratulations Mimi Xie for publishing her work “Loss of Gα12/13 Exacerbates Apical Area-dependence of Actomyosin Contractility” in Molecular Biology of the Cell! Mimi showed how apical actin density can depend on apex size. Suppressing this dependence is important to coordinate contractility across a tissue.
Frank Mason publishes Nature Cell Biology paper
Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.