Congratulation Dr. Jackson!

Congratulations Natalie on publishing her work “Actomyosin-based Tissue Folding Requires a Multicellular Myosin Gradient” in Development. Natalie discovered that a tissue-wide gradient in transcription and resulting contractility is necessary to fold a tissue. We had fun collaborating with Pearson Miller and the Dunkel Lab on this project.

Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.

Congratulations to graduate student, Mimi Xie, on passing her qualifying exam.

Biology graduate student, Natalie Heer, joins the lab. Natalie received her undergraduate degree from Harvard University where she worked in the Reck-Peterson lab on dynein motility.

Congratulations to graduate student, Jonathan Coravos, on passing his qualifying exam.

Congratulations to graduate student, Claudia Vasquez, on passing her qualifying exam.