Hannah received her Ph.D. from the Institut Curie in Paris, France. Her Bachelor’s degree is in Physics and she published a really cool paper on cells walking a “tightrope.” She is interested in collective cell behavior changing tissue shape.
Congratulations to Jaci Camuglia and Anna Yeh on passing their Ph.D. candidacy exams! Excited to see what research directions we go in over the next few years.
Congratulations to graduate student, Jonathan Jackson, on passing his qualifying exam.
Congratulations to graduate student, Mimi Xie, for her publication “Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding” in Nature Communications. In the paper, Mimi showed that cells exhibit three classes of contractile events, unconstricting, unratcheted, and ratcheted. Mimi demonstrated that cells undergo transitions between different classes of contractions, going from unconstricting or unratcheted contractions to ratcheted contractions. A transcription factor that regulates this developmental stage is important for the proper order of contractile events. It is important for cells to generate ratcheted contractions because this promotes cooperation between cells.
Congratulations to postdoc, Frank Mason, for the recent publication of his paper, “Apical domain polarization promotes actin-myosin assembly to drive ratchet-like apical constriction” on Nature Cell Biology. In the paper, Mason et al. show that the signals that regulate contractile forces in constricting cells exhibit a spatial organization within the apical domain of the cell. Signals that activate myosin motors are polarized to the center of the apical domain. Actin polymerization in this domain suppresses junctional protein localization, restricting junctional proteins to cell-cell interfaces. Thus, a “radial” cell polarity is established, which is shown to be important for apical constriction.
Congratulations to Soline on publishing her work “Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Cell Force” in Nature Communications. Soline discovered a mechanism by which tissue and organism shape can instruct cells how to generate force. This has implications in understanding how tissues and organs acquire their correct shape.
Postdoctoral fellow, Hannah Yevick, published her research titled Structural redundancy in supracellular actomyosin networks enables robust tissue folding in Developmental Cell. You can hear her talk about what she discovered in the video produced by Raleigh McElvery of the MIT Biology department. Read an MIT News article on the research.