Hannah publishes WIREs Developmental Biology review

Congratulations to graduate student, Mimi Xie, for her publication “Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding” in Nature Communications. In the paper, Mimi showed that cells exhibit three classes of contractile events, unconstricting, unratcheted, and ratcheted. Mimi demonstrated that cells undergo transitions between different classes of contractions, going from unconstricting or unratcheted contractions to ratcheted contractions. A transcription factor that regulates this developmental stage is important for the proper order of contractile events. It is important for cells to generate ratcheted contractions because this promotes cooperation between cells.

Graduate student, Jaclyn Camuglia, submitted her research “Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation” and posted a preprint. We found that morphogenetic forces are required to orient cell divisions in the Drosophila embryo through a mechanism that establishes polarity of the Pins protein.

Congratulations Soline on the publication of a book chapter Mechanical Force Sensing in Tissues!

Postdoc Mary Ann Collins publishes paper from her PhD work in Molecular Biology of the Cell. One of her microscopy images was selected for the cover!

Congratulations to Soline on publishing her work “Myosin 2-Induced Mitotic Rounding Enables Columnar Epithelial Cells to Interpret Cortical Spindle Positioning Cues” in Current Biology. Soline showed how mitotic cell rounding is critical to orient cell division such that both daughter cells remain in the tissue.

Adam Martin has been promoted to Associate Professor, effective July 1, 2016.