Fernando Melara Barahona presents poster for MSRP program

Congratulations to graduate student, Mimi Xie, for her publication “Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding” in Nature Communications. In the paper, Mimi showed that cells exhibit three classes of contractile events, unconstricting, unratcheted, and ratcheted. Mimi demonstrated that cells undergo transitions between different classes of contractions, going from unconstricting or unratcheted contractions to ratcheted contractions. A transcription factor that regulates this developmental stage is important for the proper order of contractile events. It is important for cells to generate ratcheted contractions because this promotes cooperation between cells.

Claudia Vasquez successfully defended her thesis. She gave a stellar seminar to faculty, friends, and colleagues at MIT. Nice job!

Graduate students Anna Yeh and Jaclyn Camuglia publish book chapter on morphogenesis titled Extracellular Tension and Tissue Morphogenesis.

Congratulations Mimi Xie for publishing her work “Loss of Gα12/13 Exacerbates Apical Area-dependence of Actomyosin Contractility” in Molecular Biology of the Cell! Mimi showed how apical actin density can depend on apex size. Suppressing this dependence is important to coordinate contractility across a tissue.

Congratulations to postdoc, Soline Chanet, for being awarded an EMBO Long-Term Fellowship.

Congratulations Natalie on publishing her work “Actomyosin-based Tissue Folding Requires a Multicellular Myosin Gradient” in Development. Natalie discovered that a tissue-wide gradient in transcription and resulting contractility is necessary to fold a tissue. We had fun collaborating with Pearson Miller and the Dunkel Lab on this project.